Ranolazine is used for the treatment of Angina pectoris, which has a short half-life of 1.4-1.9 hours. Ranolazine floating tablets were prepared by direct compression technique using polymers such as HPMC, Carbopol 934P and Chitosan. Tablets were evaluated for its physical properties, viz. hardness, friability, weight variation, In vitro Buoyancy, swelling studies, In vitro drug release and In-vivo gastric Residence time. Drug release kinetics was studied for zero order, first order, Higuchi and Korsmeyer-Peppas. Finally, it can be concluded that promising controlled release by gastro retentive floating tablets of Ranolazine was developed using a combination of HPMC K15M and Chitosan.

Ranolazine is used for the treatment of Angina pectoris, which has a short half-life of 1.4-1.9 hours. Ranolazine floating tablets were prepared by direct compression technique using polymers such as HPMC, Carbopol 934P and Chitosan. Tablets were evaluated for its physical properties, viz. hardness, friability, weight variation, In vitro Buoyancy, swelling studies, In vitro drug release and In-vivo gastric Residence time. Drug release kinetics was studied for zero order, first order, Higuchi and Korsmeyer-Peppas. Finally, it can be concluded that promising controlled release by gastro retentive floating tablets of Ranolazine was developed using a combination of HPMC K15M and Chitosan.

Action, Geheimnisse und die Chance auf Erlösung erwarten dich in dem düsteren Action-Ego-Puzzle GRAVEN. Erkunde als zu Unrecht verurteilter Mann des Glaubens eine düstere Fantasy-Welt. Kämpfe gegen die Schrecken der Menschheit, die Wildnis und darüber hinaus, indem du die Umgebung, Magie und Waffen nutzt. Als treuer Priester des orthogonalen Ordens, der wegen eines Verbrechens zur Verteidigung eines anderen zum Tode verurteilt wurde, lebst du wieder in einem kleinen Boot, das in einem Sumpf treibt. Ein Fremder bringt dich auf festen Boden und übergibt dir vage Anweisungen sowie einen geheimnisvollen Stab und ein Buch. Geh hinaus, frommer Priester, lindere das Leid, decke Täuschungen auf und zerschlage die unheimlichen Perversionen, die die Realität selbst bedrohen. Die Verbindung von modernen Entwicklungstools und -techniken mit der Ästhetik der späten 90er Jahre erweckt den Action-Ego-Puzzler GRAVEN zum Leben, mit Charakterdesigns von Chuck Jones (Duke Nukem 3D, Half-Life) und der Stimme von Stephan Weyte (Blood, Fire Emblem,

»Der aktuell einflussreichste Vordenker der westlichen Welt.« (New York Times) Mit seinem internationalen Bestseller 12 Rules for Life half Professor Jordan B. Peterson als Psychologe und gefeierter Professor an der Harvard University Millionen von Menschen, Ordnung in das Chaos ihres Lebens zu bringen. In Beyond Order - Jenseits der Ordnung konzentriert er sich auf die Gefahr, die von zu viel Struktur ausgeht. Er liefert zwölf weitere lebensrettende Prinzipien, die helfen, unserem ewigen Wunsch, die Welt zu ordnen, zu widerstehen. Denn ein Übermaß an Ordnung fordert unweigerlich seinen Tribut: Sie lässt uns bis zur Unterwerfung versteinern. Denn zu viel Sicherheit ist ebenso gefährlich wie ein Übermaß an Chaos, das uns mit Instabilität und Angst bedroht. Stattdessen sollten wir uns auf unseren Instinkt verlassen, um Sinn und Zweck zu finden, auch - und gerade - wenn wir uns machtlos fühlen. Jenseits der Ordnung ist ein Aufruf, die beiden grundlegenden Prinzipien der Realität - Chaos und Ordnung - ins Gleichgewicht zu bringen und den schmalen Pfad mutig zu beschreiten, der sie trennt.

Ed Nelson is struggling to recover from the devastating loss of his wife to cancer. As Ed's depression begins to deepen, his older brother steps in to help him make the critical changes necessary to bring him back from the brink. Into this new environment walks Tanya, a woman half his age, who immediately reminds him of his late wife. Ed and Tanya develop an unlikely friendship, but as things quickly evolve into something more intimate, he must now confront what it means to be a widower making sense of a life full of new and unexpected complications.

Action, Geheimnisse und die Chance auf Erlösung erwarten dich in dem düsteren Action-Ego-Puzzle GRAVEN. Erkunde als zu Unrecht verurteilter Mann des Glaubens eine düstere Fantasy-Welt. Kämpfe gegen die Schrecken der Menschheit, die Wildnis und darüber hinaus, indem du die Umgebung, Magie und Waffen nutzt. Als treuer Priester des orthogonalen Ordens, der wegen eines Verbrechens zur Verteidigung eines anderen zum Tode verurteilt wurde, lebst du wieder in einem kleinen Boot, das in einem Sumpf treibt. Ein Fremder bringt dich auf festen Boden und übergibt dir vage Anweisungen sowie einen geheimnisvollen Stab und ein Buch. Geh hinaus, frommer Priester, lindere das Leid, decke Täuschungen auf und zerschlage die unheimlichen Perversionen, die die Realität selbst bedrohen. Die Verbindung von modernen Entwicklungstools und -techniken mit der Ästhetik der späten 90er Jahre erweckt den Action-Ego-Puzzler GRAVEN zum Leben, mit Charakterdesigns von Chuck Jones (Duke Nukem 3D, Half-Life) und der Stimme von Stephan Weyte (Blood, Fire Emblem,

Bloomsbury presents Seven Million Sunflowers by Malcolm Duffy, read by Amrita Acharia. Escaping war is only half the battle as the Kovalenko family swap Ukrainian dangers for life with a British family. 15-year-old Kateryno and her family live in Kharkiv. Their lives are shattered when on February 24th 2022 the Russian army invades. Their apartment block is struck by a missile. After weeks living in their basement, Kateryno, her mother, and brother, decide to leave, joining seven million Ukrainian refugees. They come to England and meet their host family, the Hawkins. But their new beginning brings a whole new set of problems.

Los Angeles, 15th January 1947. A beautiful young woman walks into the night and meets a horrific destiny . Five days later, her tortured body is found drained of blood and cut in half. The newspapers call her 'The Black Dahlia'. For two cops, what begins as an investigation becomes a hellish journey that takes them to the core of the dead girl's twisted life. And soon professional curiosity spirals into obsession... __________ 'A mesmerising study of the psycho-sexual obsession... extraordinarily well written' - The Times 'The outstanding crime writer of his generation' - The Independent 'A wonderful tale of ambition, insanity, passion and deceit' - Publishers Weekly

The hilarious new series perfect for fans of Loki, Amelia Fang and Hotel Transylvania. Welcome to Hawthorne Manor, a wacky old house with a creepy secret - it's full of VAMPIRES! But Moth is only a half-vampire (that's what happens if you get bitten by a vamp with just one fang) so he can't fly and HATES the sight of blood. Bullied by the other vampires, Moth's life SUCKS - until a group of school children unexpectedly turn up, led by a cheerful, confident girl called Mina. Can Moth protect his new friend from the other vamps? Or is Mina destined to become their dinner?

Philip Roth's writing career spans a remarkable five decades, a period that has seen him rise to become one of the greatest chroniclers of post-war American life. Collected here are some of the finest interviews, essays and articles discussing his own fiction and the range of controversies that it sparked, including his long interview with the Paris Review. Here too are Roth's writings on American fiction, Milan Kundera, baseball, and his deep admiration for Franz Kafka. Coursing through each of these pieces is the Sheer Playfulness and Deadly Seriousness that have defined Roth's writing for half a century.

Leichtigkeit, ein weites Sichtfeld und Aufmerksamkeit für das Design definieren das Herz von SPINSHIELD AIR, das dank seines Half Rim-Rahmens perfekt für diejenigen ist, die einen leichten und wirkungsvollen Stil suchen. An komfortrelevanten technischen Features wie der ergonomischen „Pro-Fit“-Geometrie der Bügel, die jederzeit für einen stabilen und bequemen Sitz sorgen soll, sowie den „Ultra Grip“-Endstücken aus weichem Gummi mangelt es nicht und Nasenpads. SPINSHIELD AIR stellt auch eine optische Lösung vor, die bei Sportlern für diese Art von Produkt sehr gefragt ist. Rudy Project bestätigt seinen Fokus auf verschreibungspflichtige Lösungen für den Sport, indem es dieses Lifestyle-Modell dank eines neuen optischen Einsatzes, der speziell für Zylinderlinsen entwickelt wurde, mit RX-Lösungen kompatibel macht. MERKMALE Sicherheitsscharniere No Slip Grip Bügel Rutschfeste Nasenpads PANORAMISCHE FLACHLINSE Die weit umlaufende tiefe Horizont-Zylinderlinse Spinshield Air hat die doppelte Funktion, maximale Abdeckung für Ihre Auge

A new game in foilEdition: BoxedLanguage version: English, German subtitlesCover language: MultilingualAls gläubiger Priester des orthogonischen Ordens werden Sie wegen eines Verbrechens zur Verteidigung eines Unschuldigen zum Tode verurteilt und des Landes verwiesen. Sie wachen auf einem kleinen Boot auf, das durch die Moore treibt. Ein mysteriöser Fremder bringt dich aufs Festland und gibt dir eine geheimnisvolle Warnung, einen Stab und ein Buch. Mach dich auf den Weg, frommer Priester, überlebe das Leid, entlarve die Unwahrheit und vernichte die uralten Schrecken, die die Wirklichkeit selbst bedrohen. Vielleicht wirst du dabei deinen Seelenfrieden finden? Das Ego-Action-Adventure von GRAVEN kombiniert moderne Produktionsmittel und -techniken mit der Ästhetik der 90er Jahre und erwacht zum Leben! Charakterdesigns von Chuck Jones (Duke Nukem 3d, Half-Life) und Synchronrollen von Stephan Weyte (Blood, Fire Emblem, Dusk) unterstreichen dieses dunkle und unverwechselbare mittelalterliche Fantasy-Abenteuer. HIGHLIGHTS - Lösen Sie

»Der aktuell einflussreichste Vordenker der westlichen Welt.« (New York Times) Mit seinem internationalen Bestseller 12 Rules for Life half Professor Jordan B. Peterson als Psychologe und gefeierter Professor an der Harvard University Millionen von Menschen, Ordnung in das Chaos ihres Lebens zu bringen. In Beyond Order – Jenseits der Ordnung konzentriert er sich auf die Gefahr, die von zu viel Struktur ausgeht. Er liefert zwölf weitere lebensrettende Prinzipien, die helfen, unserem ewigen Wunsch, die Welt zu ordnen, zu widerstehen. Denn ein Übermaß an Ordnung fordert unweigerlich seinen Tribut: Sie lässt uns bis zur Unterwerfung versteinern. Denn zu viel Sicherheit ist ebenso gefährlich wie ein Übermaß an Chaos, das uns mit Instabilität und Angst bedroht. Stattdessen sollten wir uns auf unseren Instinkt verlassen, um Sinn und Zweck zu finden, auch – und gerade – wenn wir uns machtlos fühlen. Jenseits der Ordnung ist ein Aufruf, die beiden grundlegenden Prinzipien der Realität – Chaos und Ordnung – ins Gleichgewicht zu bringen und den schmalen Pfad mutig zu beschreiten, der sie trennt.

How long can a cause remain just, when painted in the blood of innocence? They named her the Starhammer once. Hero to some, monster to many more. First into the breach at the Shattering, anointed in the blood of a thousand demons. The last of the legendary Valkyr. But the Starhammer is dead. Or so all the stories tell. Amidst the soaring trees and haunted slopes of the Primals, Selitha relies on the forest to provide, and cares for her family. Nothing is more precious to her than her daughter. It is a simple life. It is a peaceful life. It is a lie. When bandits raid the Primals, burning towns and stealing children from their beds, Selitha has no choice but to lend her axe to the rescue. Volcanic giants spew ash into the sky, demonic bears claw the forest to splinters, and there are even rumours the kin, half-men half-beasts, serve the raiders. All the Terrors of the old world stand against her. With a severed head as guide, to rescue the children, Selitha may need to bring the Starhammer back from the dead. But will it be the hero who rises from the grave, or the monster? -- A new standalone fantasy adventure set in the world of the God Eater Saga. Inspired by Norse mythology and the God of War games, it's perfect for readers of John Gwynne's Bloodsworn Saga.

Clean air is essential for all living creatures—plants; animals, and people—to live healthy lives. Every Breath We Take is a positive, life-affirming look at clean air, with a subtle message about how air can be dirtied—and how it can be cleaned up. Photographs of beautiful children around the world exploring air through touch, smell, sound, and sight underscore the importance of clean air to all life on earth. This is science that surrounds us. The first step to cherishing something is recognizing its importance and understanding why it is necessary. A portion of the proceeds from the sales of this book will be donated to Moms Clean Air Force, a national movement of over a half million moms, dads, and grandparents who are protecting the right of every child to breathe clean air.

Can you learn to be lucky? Self-made millionaire Denise Duffield-Thomas not only believes this is possible, she knows it's possible. From being broke, hating her office job and generally having a life that made her completely miserable, Denise went on to travel the world and make all of her dreams come true within the space of a few years. She attracted more than half a million dollars- worth of free travel, scholarships, prizes and bank errors in her favour, and in this book she reveals how you can do the same. Whether you're already lucky and want to attract even more into your life, or you feel like your luck is just about to run out, Lucky Bitch will show you how to take action in areas of your life that are lacking in magic. With her trademark humour and encouragement, Denise gives clear and effective instructions based on the principles of the Law of Attraction to get you closer to living your dream life. You'll also learn the 'Ten Lucky Bitch Commandments' and how to use them to create luck in all areas of life, including business and money. This book has already changed the lives of tens of thousands of people. Now it has the potential to change yours. If you've been asking for an answer or a miracle, this book is it!

What if Ponce de Leon was right, and there truly exists a fountain of youth somewhere? Would you take a drink? Indeed, everything you've heard is true, but only half-true. Such a fountain exists, and the water gives life. But it demands it too. Once a sip is taken, the waters within come calling, awakening a need within those who have had a drink to kill so the water can replenish the stores of life giving power flowing from the fountain. But there is a safeguard--a family who has passed down guardianship of the water from generation to generation. Guardian tells the story of Norman, who struggles to come into his new role and ultimately makes a decision that will alter the course for those across the generations who have taken a drink from the deadly spring.

Clean air is essential for all living creatures—plants; animals, and people—to live healthy lives. Every Breath We Take is a positive, life-affirming look at clean air, with a subtle message about how air can be dirtied—and how it can be cleaned up. Photographs of beautiful children around the world exploring air through touch, smell, sound, and sight underscore the importance of clean air to all life on earth. This is science that surrounds us. The first step to cherishing something is recognizing its importance and understanding why it is necessary. A portion of the proceeds from the sales of this book will be donated to Moms Clean Air Force, a national movement of over a half million moms, dads, and grandparents who are protecting the right of every child to breathe clean air.

Are you in charge of your life? Or are you being swept away by things that are seemingly out of your control? In AWAKEN THE GIANT WITHIN, Anthony Robbins, the bestselling author of UNLIMITED POWER, shows the reader how to take immediate control of their mental, emotional, physical and financial destiny.Anthony Robbins has devoted more than half his life to helping people discover and develop their own unique qualities of greatness. He is considered one the world's leading exponents in the science of peak performance and is committed to assisting people in achieving personal and professionl mastery. 'AWAKEN THE GIANT WITHIN is a fascinating, intriguing presentation of cutting edge findings and insights across a broad spectrum of issues, including the growing consciousness that true success is anchored in enduring values and service to others' STEPHEN R. COVEY Author of bestselling THE 7 HABITS OF HIGHLY EFFECTIVE PEOPLE

From #1 New York Times bestselling author Abbi Glines comes the next new adult novel in the Rosemary Beach series, in which we meet Mase, a Texas heartthrob first introduced in Take a Chance who comes to Rosemary Beach to stir things up. I had an urge to fix all her problems. Which was stupid. She was doing fine without me. But something about those big eyes... Mase Colt-Manning has always preferred his humble life as a Texas rancher to his birthright as the son of a legendary rock star. In fact, he rarely visits his father's rarefied world in Rosemary Beach, especially if it means bunking at his vile half-sister Nan's house?until one visit leads to a chance encounter with a young, gorgeous house maid who awakens him with her off-key but spirited imitation of a country music star... Reese Ellis finally has her freedom. After escaping a lifetime of abuse from her parents and classmates for an undiagnosed learning disorder, she seizes the opportunity to be a house maid to some of the richest families in Rosemary Beach. But her job is in jeopardy when she causes an accident at the home of her most important client, Nan Dillon. When a hot, half-naked stranger with a cowboy's swagger comes to her rescue, she's intrigued?then afraid once he shows his own interest. Reese has never met a trustworthy man in her life. Will Mase be any different?