Chuck Palahniuk showed himself to be his generation's most visionary satirist in this, his first book. Fight Club's estranged narrator leaves his lackluster job when he comes under the thrall of Tyler Durden, an enigmatic young man who holds secret after-hours boxing matches in the basements of bars. There, two men fight "as long as they have to." This is a gloriously original work that exposes the darkness at the core of our modern world.

Over the last half century, a quiet revolution has taken place. In a series of breathtaking discoveries, biochemist Thomas Cech and a diverse cast of brilliant scientists have revealed RNA at the centre of biology's greatest mysteries, from how life began to what makes us human to why we age. At last, The Catalyst pulls back the curtain to show how RNA-long sidelined as the passive servant of DNA-defines life from its very origins to our future in the twenty-first century. Recounting his own paradigm-shifting discovery that RNA can catalyse biochemical reactions, as well as his work on the "fountain of youth" telomerase, Cech unfolds how RNA holds the key to the intricate machinery of our cells, the critical processes of ageing and disease and the spectacular powers of breakthrough therapies from CRISPR to mRNA vaccines. From one of our foremost scientists, The Catalyst is a must-read guide to the present and future of biology and medicine.

*Volga Blues * - A Journey into the Heart of Russia / 31.49€ / Buch

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The Selected Writings of Edgar Allan Poe - A Norton Critical Edition: Authoritative Texts, Backgrounds and Contexts, Criticism (Norton Critical Editions, Band 0)

Set in interwar Germany, The Intermediaries tells the forgotten story of the Institute for Sexual Science, the world's first centre for homosexual and transgender rights. Headed by a gay Jewish man, Dr. Magnus Hirshfeld, the institute aided in the first gender-affirming surgeries and hormone replacements, acting as a rebellious base of operations in the face of rising prejudice, nationalism and Nazi propaganda. Brandy Schillace introduces readers to Dora Richter, an institute patient whom we follow from early desperate years to gender-affirming care and her right to live as a woman. She offers an example of queer resilience in the face of punishing cultural constraints. The Intermediaries charts the interdependent relationships between nascent sexual science, queer civil rights and the fight against fascism. It tells riveting stories of LGBTQ pioneers, a surprising, long-suppressed history and offers a cautionary tale in the face of today's oppressive anti-trans legislation.

Mister Norton's New Hat

Mr Norton's New Truck

For over half a century, DNA has dominated science and the popular imagination as the "secret of life". But over the last several decades, a quiet revolution has taken place. In a series of breathtaking discoveries, the biochemist Thomas R. Cech and a diverse cast of brilliant scientists have revealed that RNA-long overlooked as the passive servant of DNA-sits at the centre of biology's greatest mysteries. In The Catalyst, Cech brings together years of research to demonstrate that RNA is the true key to understanding life on Earth, from its origins to our future in the twenty-first century. A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyse cellular reactions, to the cutting-edge biotechnologies poised to reshape our health. We learn how RNA-once thought merely to transmit DNA's genetic instructions to the cell's protein-making machinery-may have jump-started life itself, and how, at the same time, it can cut our individual lives short through viral diseases and cancer. We see how RNA is implicated in the ageing process and explore the darker depths of the supposed fountain of youth, telomerase. And we catch a thrilling glimpse into how RNA-powered therapies-from CRISPR, the revolutionary tool that uses RNA to rewrite the code of life, to the groundbreaking mRNA vaccines that have saved millions during the pandemic, and more-may enable us to improve and even extend life beyond nature's current limits. The Catalyst is a must-read guide to the present and future of biology and medicine.

Written during the most eventful years of Benjamin Franklin's life (1771-90), the Autobiography is one of the most influential memoirs in history. This newly edited Norton Critical Edition includes an introduction that explains the history of the Autobiography within the larger history of the life-writing genre as well as within the history of celebrity. The text is accompanied by new and expanded explanatory annotations and by a map, an illustration, and six facsimiles. "Contexts" presents a broader view of Franklin's life with a journal entry from a 1726 voyage, correspondence, a Poor Richard piece on ambition and fame, Franklin's views on self-improvement, and his last will (and codicil). "Criticism" draws on a wealth of material that reflects both the wide range of Franklin's achievements and the global impact of his life and memoirs. New international voices in "Contemporary Opinions" include Immanuel Kant, Honoré Gabriel Riqueti, Comte de Mirabeau, José Antonio de Alzate y Ramírez, and José Francisco Correia da Serra. "Nineteenth-Century Opinions" includes Humphry Davy on Franklin's discovery of electricity as well as Empress Shoken of Japan's Franklin-inspired poem. Finally, "Modern Opinions" reprints important pieces: I. B. Cohen on Franklin and the Autobiography's importance to science; Michael Warner's theoretical interpretation of the practices of writing and printing and what they tell us about Franklin; and Peter Stallybrass's insightful and engaging history-of-the-book perspective on Franklin's writing generally and the Autobiography specifically. A Chronology of Franklin's life, a Selected Bibliography, and an Index are also included.

M14 Sechskant-Adapter M14 x Sechskant Adapter

In Öl eingeweicht Das gebogene Steinprofil ermöglicht ein schnelles und einfaches Schärfen von alle/Cur Anzahl der Packungen: 1 Farbe: Mehrfarbig

Release: 00.00.0000, Format: Vinyl Maxi, Neuware, Inhalt: 1 Discs, Label/ Hersteller: Norton