Songs of the Wagonmaster by Ken Hudson & Fran

Hudson Valley Wildlife Coloring Book: Inspired by photography by Debs Creative Images (Wildlife & Nature Escape Coloring Series)

NEW YORK NOTEBOOK: Hudson Yards The Future Has Always Been Built by Those Who Dared. 30Lines

The Purple Land is W. H. Hudson's exuberant romance of wandering, set in nineteenth-century Uruguay, a country of civil strife, pastoral beauty, and improvisatory freedom. Following the English adventurer Richard Lamb through encounters with soldiers, gauchos, rebels, and independent women, the novel blends picaresque comedy, travel narrative, political romance, and nature writing. Its loose, episodic form belongs to the tradition of Cervantine adventure, yet its sensuous landscapes and anti-imperial undertone give it a distinctively modern vitality. Hudson was exceptionally equipped to write such a book. Born in Argentina to American parents and later settled in England, he carried into English literature an intimate knowledge of the Río de la Plata region, its birds, plains, customs, and violent political histories. A naturalist as well as a novelist, Hudson transformed firsthand observation into fiction, opposing metropolitan assumptions with a vision of South America as morally complex, beautiful, and resistant to possession. This book is recommended to readers who value adventure enriched by intelligence, landscape rendered with lyrical precision, and fiction that questions colonial ambition without sacrificing narrative pleasure. The Purple Land remains one of Hudson's most engaging works: romantic, comic, politically alert, and alive to the freedom and danger of the open country.

Green Mansions (1904) is a haunting romance of the South American forest, narrated by Abel, a political fugitive who discovers Rima, the mysterious, bird-voiced girl of the woods. Hudson fuses adventure narrative, pastoral elegy, and fin-de-siècle symbolism into prose of luminous natural observation. Its lyric descriptions of tropical vegetation, animal life, and indigenous legend place it between Victorian romance and modern ecological fiction, while its tragic plot questions conquest, possession, and the dream of untouched nature. W. H. Hudson was unusually equipped to imagine such a book. Born in Argentina to American parents and later settled in England, he was both an expatriate writer and a respected naturalist, especially attentive to birds and landscapes. His childhood on the pampas, scientific habits of seeing, and persistent sense of displacement inform Abel's wonder, Rima's otherness, and the novel's melancholy awareness that Edenic places are always vulnerable to violence. Readers drawn to literary romance, environmental writing, or early twentieth-century mythmaking will find Green Mansions richly rewarding. It is not merely an exotic love story, but a subtle meditation on beauty, extinction, and the human desire to name and possess what should remain free.

The Purple Land is W. H. Hudson's exuberant romance of wandering, set in nineteenth-century Uruguay, a country of civil strife, pastoral beauty, and improvisatory freedom. Following the English adventurer Richard Lamb through encounters with soldiers, gauchos, rebels, and independent women, the novel blends picaresque comedy, travel narrative, political romance, and nature writing. Its loose, episodic form belongs to the tradition of Cervantine adventure, yet its sensuous landscapes and anti-imperial undertone give it a distinctively modern vitality. Hudson was exceptionally equipped to write such a book. Born in Argentina to American parents and later settled in England, he carried into English literature an intimate knowledge of the Río de la Plata region, its birds, plains, customs, and violent political histories. A naturalist as well as a novelist, Hudson transformed firsthand observation into fiction, opposing metropolitan assumptions with a vision of South America as morally complex, beautiful, and resistant to possession. This book is recommended to readers who value adventure enriched by intelligence, landscape rendered with lyrical precision, and fiction that questions colonial ambition without sacrificing narrative pleasure. The Purple Land remains one of Hudson's most engaging works: romantic, comic, politically alert, and alive to the freedom and danger of the open country.

Green Mansions (1904) is a haunting romance of the South American forest, narrated by Abel, a political fugitive who discovers Rima, the mysterious, bird-voiced girl of the woods. Hudson fuses adventure narrative, pastoral elegy, and fin-de-siècle symbolism into prose of luminous natural observation. Its lyric descriptions of tropical vegetation, animal life, and indigenous legend place it between Victorian romance and modern ecological fiction, while its tragic plot questions conquest, possession, and the dream of untouched nature. W. H. Hudson was unusually equipped to imagine such a book. Born in Argentina to American parents and later settled in England, he was both an expatriate writer and a respected naturalist, especially attentive to birds and landscapes. His childhood on the pampas, scientific habits of seeing, and persistent sense of displacement inform Abel's wonder, Rima's otherness, and the novel's melancholy awareness that Edenic places are always vulnerable to violence. Readers drawn to literary romance, environmental writing, or early twentieth-century mythmaking will find Green Mansions richly rewarding. It is not merely an exotic love story, but a subtle meditation on beauty, extinction, and the human desire to name and possess what should remain free.

Bloomsbury presents Sun Country by Howard Cunnell, read by Paul Thornley. 'One of Britain's most distinctive and trustworthy voices ... A beautiful book' TIM WINTON 'A book to lose yourself inside, and emerge from with enhanced clarity and wisdom' FRANCES WILSON 'Tender and unflinching ... A masterclass in clarity and feeling' JIM CRACE 'Cunnell writes with so much sensitivity to the sacredness of the everyday' SARA BAUME A beautifully written, courageous and deeply moving journey from sorrow to acceptance, from loss to hope, shimmering with coastal light and hard-won wisdom. In Sun Country, Howard Cunnell returns to the southern England beachlands of his boyhood after the death of his mother. A love letter to the changing coast and sea, Sun Country is a book alive with light and shadow, where the white spaces between words are as charged with tension and power as the words themselves. It is a reckoning with the things we inherit – silence and absence, stories told and untold – and the transgression involved in turning a life into art. At the heart of the book is Gillian, his devoted single mother, and the small yet unforgettable details of her life that are woven into a powerful meditation on impermanence, grief, class and solitude. At once intimate and expansive, this luminous memoir traces one man's journey from loss back towards life. Through stories about the writers and painters with whom he feels a kinship – including the English Romantics, W. H. Hudson and Agnes Martin – and the history of his own Sussex working-class family, Cunnell writes his way home to a place, to a culture and to himself as an artist. Cunnell's descriptive power, so widely praised in his first memoir, reaches a new breathtaking level, with the simplicity that only comes from the finest craft and poetry.

NEW YORK TIMES BESTSELLER • The true tale of the 1893 World's Fair in Chicago and the cunning serial killer who used the magic and majesty of the fair to lure his victims to their death. A Kirkus Reviews Best Nonfiction Book of the Century Two men, each handsome and unusually adept at his chosen work, embodied an element of the great dynamic that characterized America’s rush toward the twentieth century. The architect was Daniel Hudson Burnham, the fair’s brilliant director of works and the builder of many of the country’s most important structures, including the Flatiron Building in New York and Union Station in Washington, D.C. The murderer was Henry H. Holmes, a young doctor who, in a malign parody of the White City, built his “World’s Fair Hotel” just west of the fairgrounds—a torture palace complete with dissection table, gas chamber, and 3,000-degree crematorium. Burnham overcame tremendous obstacles and tragedies as he organized the talents of Frederick Law Olmsted, Charles McKim, Louis Sullivan, and others to transform swampy Jackson Park into the White City, while Holmes used the attraction of the great fair and his own satanic charms to lure scores of young women to their deaths. What makes the story all the more chilling is that Holmes really lived, walking the grounds of that dream city by the lake. The Devil in the White City draws the reader into a time of magic and majesty, made all the more appealing by a supporting cast of real-life characters, including Buffalo Bill, Theodore Dreiser, Susan B. Anthony, Thomas Edison, Archduke Francis Ferdinand, and others. Erik Larson’s gifts as a storyteller are magnificently displayed in this rich narrative of the master builder, the killer, and the great fair that obsessed them both.

NEW YORK TIMES BESTSELLER The true tale of the 1893 World's Fair in Chicago and the cunning serial killer who used the magic and majesty of the fair to lure his victims to their death. A Kirkus Reviews Best Nonfiction Book of the Century Two men, each handsome and unusually adept at his chosen work, embodied an element of the great dynamic that characterized America’s rush toward the twentieth century. The architect was Daniel Hudson Burnham, the fair’s brilliant director of works and the builder of many of the country’s most important structures, including the Flatiron Building in New York and Union Station in Washington, D.C. The murderer was Henry H. Holmes, a young doctor who, in a malign parody of the White City, built his “World’s Fair Hotel” just west of the fairgrounds—a torture palace complete with dissection table, gas chamber, and 3,000-degree crematorium. Burnham overcame tremendous obstacles and tragedies as he organized the talents of Frederick Law Olmsted, Charles McKim, Louis Sullivan, and others to transform swampy Jackson Park into the White City, while Holmes used the attraction of the great fair and his own satanic charms to lure scores of young women to their deaths. What makes the story all the more chilling is that Holmes really lived, walking the grounds of that dream city by the lake. The Devil in the White City draws the reader into a time of magic and majesty, made all the more appealing by a supporting cast of real-life characters, including Buffalo Bill, Theodore Dreiser, Susan B. Anthony, Thomas Edison, Archduke Francis Ferdinand, and others. Erik Larson’s gifts as a storyteller are magnificently displayed in this rich narrative of the master builder, the killer, and the great fair that obsessed them both.

#1 NATIONAL BESTSELLER • NATIONAL BOOK AWARD FINALIST • From the #1 New York Times bestselling author of The Splendid and the Vile comes the true tale of the 1893 World's Fair in Chicago and the cunning serial killer who used the magic and majesty of the fair to lure his victims to their death. “As absorbing a piece of popular history as one will ever hope to find.” —San Francisco Chronicle A Kirkus Reviews Best Nonfiction Book of the Century • A Los Angeles Times Best Nonfiction Book of the Last 30 Years Combining meticulous research with nail-biting storytelling, Erik Larson has crafted a narrative with all the wonder of newly discovered history and the thrills of the best fiction. Two men, each handsome and unusually adept at his chosen work, embodied an element of the great dynamic that characterized America’s rush toward the twentieth century. The architect was Daniel Hudson Burnham, the fair’s brilliant director of works and the builder of many of the country’s most important structures, including the Flatiron Building in New York and Union Station in Washington, D.C. The murderer was Henry H. Holmes, a young doctor who, in a malign parody of the White City, built his “World’s Fair Hotel” just west of the fairgrounds—a torture palace complete with dissection table, gas chamber, and 3,000-degree crematorium. Burnham overcame tremendous obstacles and tragedies as he organized the talents of Frederick Law Olmsted, Charles McKim, Louis Sullivan, and others to transform swampy Jackson Park into the White City, while Holmes used the attraction of the great fair and his own satanic charms to lure scores of young women to their deaths. What makes the story all the more chilling is that Holmes really lived, walking the grounds of that dream city by the lake. The Devil in the White City draws the reader into the enchantment of the Guilded Age, made all the more appealing by a supporting cast of real-life characters, including Buffalo Bill, Theodore Dreiser, Susan B. Anthony, Thomas Edison, Archduke Francis Ferdinand, and others. Erik Larson’s gifts as a storyteller are magnificently displayed in this rich narrative of the master builder, the killer, and the great fair that obsessed them both.

#1 NATIONAL BESTSELLER NATIONAL BOOK AWARD FINALIST From the #1 New York Times bestselling author of The Splendid and the Vile comes the true tale of the 1893 World's Fair in Chicago and the cunning serial killer who used the magic and majesty of the fair to lure his victims to their death. “As absorbing a piece of popular history as one will ever hope to find.” —San Francisco Chronicle A Kirkus Reviews Best Nonfiction Book of the Century A Los Angeles Times Best Nonfiction Book of the Last 30 Years Combining meticulous research with nail-biting storytelling, Erik Larson has crafted a narrative with all the wonder of newly discovered history and the thrills of the best fiction. Two men, each handsome and unusually adept at his chosen work, embodied an element of the great dynamic that characterized America’s rush toward the twentieth century. The architect was Daniel Hudson Burnham, the fair’s brilliant director of works and the builder of many of the country’s most important structures, including the Flatiron Building in New York and Union Station in Washington, D.C. The murderer was Henry H. Holmes, a young doctor who, in a malign parody of the White City, built his “World’s Fair Hotel” just west of the fairgrounds—a torture palace complete with dissection table, gas chamber, and 3,000-degree crematorium. Burnham overcame tremendous obstacles and tragedies as he organized the talents of Frederick Law Olmsted, Charles McKim, Louis Sullivan, and others to transform swampy Jackson Park into the White City, while Holmes used the attraction of the great fair and his own satanic charms to lure scores of young women to their deaths. What makes the story all the more chilling is that Holmes really lived, walking the grounds of that dream city by the lake. The Devil in the White City draws the reader into the enchantment of the Guilded Age, made all the more appealing by a supporting cast of real-life characters, including Buffalo Bill, Theodore Dreiser, Susan B. Anthony, Thomas Edison, Archduke Francis Ferdinand, and others. Erik Larson’s gifts as a storyteller are magnificently displayed in this rich narrative of the master builder, the killer, and the great fair that obsessed them both.

A COMPLETE, UNCOMPLICATED GUIDE TO THE SCIENCE OF LIFE, THE UNIVERSE AND EVERYTHING INBETWEEN ' Most scientists know only their own field. Tim Coulson is at home with science as an integrated whole. A pleasure to read, and a lasting accomplishment' Richard Dawkins ' Step aside Star Wars - ours is the most astonishing origin story you'll ever hear and its beautifully told by Tim Coulson ' Professor Ken Norris, Deputy Director of Science at the Natural History Museum -- What made the universe? How did we come to exist? Where are we going? Once, such questions belonged to religion or philosophy. But in the last century scientists have been uncovering astonishing answers to explain the wonder of ourselves, our world and our universe. Professor Tim Coulson takes us back to the beginning of everything - the Big Bang 13.8 million years ago - and tells us the epic story of how we came to be. From the emergence of the first atom to the mysteries of human consciousness, this book is, in short, the complete and utter history of everything. -- 'A highly readable and super enjoyable book . . . that takes us on a free-spirited intellectual romp through every aspect of what we know about our universe' Peter Hudson FRS Willaman Professor of Biology at Penn State 'A charming, engaging and erudite account' David Christian, author of New York Times bestseller Origin Story (2018) 'A gangbuster science book. A can't-put-down read. I don't think I have learned more from a single book' Douglas W. Smith, Former Senior Wildlife Biologist, Yellowstone National Park 'Exceptional. A highly infectious read. From the first page I found it impossible to put down' Professor Baroness Kathy Willis, Professor of Biodiversity, University of Oxford 'Achieves something almost impossible, lucid explanation without dumbing down . . . can read this for fun and accidentally you will know as much general science as any Professor' James H Naismith FRS FRSE FMedSci MAE, Head of the Mathematical, Physical and Life Sciences Division at Oxford, Professor of Structural Biology 'With wit, wisdom and humility. The prose is of a perfect weight, and an absolute joy to read' Sunetra Gupta, Professor of Theoretical Epidemiology at the University of Oxford 'Will appeal to a broad variety of readers and inspire new generations of scientists for years to come' Quentin Paynter

A COMPLETE, UNCOMPLICATED GUIDE TO THE SCIENCE OF LIFE, THE UNIVERSE AND EVERYTHING INBETWEEN ' Most scientists know only their own field. Tim Coulson is at home with science as an integrated whole. A pleasure to read, and a lasting accomplishment' Richard Dawkins ' Step aside Star Wars - ours is the most astonishing origin story you'll ever hear and its beautifully told by Tim Coulson ' Professor Ken Norris, Deputy Director of Science at the Natural History Museum -- What made the universe? How did we come to exist? Where are we going? Once, such questions belonged to religion or philosophy. But in the last century scientists have been uncovering astonishing answers to explain the wonder of ourselves, our world and our universe. Professor Tim Coulson takes us back to the beginning of everything - the Big Bang 13.8 million years ago - and tells us the epic story of how we came to be. From the emergence of the first atom to the mysteries of human consciousness, this book is, in short, the complete and utter history of everything. -- 'A highly readable and super enjoyable book . . . that takes us on a free-spirited intellectual romp through every aspect of what we know about our universe' Peter Hudson FRS Willaman Professor of Biology at Penn State 'A charming, engaging and erudite account' David Christian, author of New York Times bestseller Origin Story (2018) 'A gangbuster science book. A can't-put-down read. I don't think I have learned more from a single book' Douglas W. Smith, Former Senior Wildlife Biologist, Yellowstone National Park 'Exceptional. A highly infectious read. From the first page I found it impossible to put down' Professor Baroness Kathy Willis, Professor of Biodiversity, University of Oxford 'Achieves something almost impossible, lucid explanation without dumbing down . . . can read this for fun and accidentally you will know as much general science as any Professor' James H Naismith FRS FRSE FMedSci MAE, Head of the Mathematical, Physical and Life Sciences Division at Oxford, Professor of Structural Biology 'With wit, wisdom and humility. The prose is of a perfect weight, and an absolute joy to read' Sunetra Gupta, Professor of Theoretical Epidemiology at the University of Oxford 'Will appeal to a broad variety of readers and inspire new generations of scientists for years to come' Quentin Paynter

PICO 7 kanisterloses Unterdruck-Wundtherapiesystem Das System ist tragbar, leicht und diskret - für mehr Patientenfreiheit.17-20 Produkteigenschaften Das PICO 7 kanisterlose Unterdruck-Wundtherapiesystem verfügt über die AIRLOCK-Technologie So wird ein konstanter Unterdruck abgegeben - bis zu 7 Tage Der Unterdruck von -80mmHG wird über die gesamte Wundauflage aufrechterhalten - dank des einzigartigen Verbanddesigns wird so ein erweitertes Therapieareal der Vakuumversiegelung ermöglicht Auch ohne vollständige Versiegelung (Leckage)***5 Oder schwer zu verbindenden Körperkonturen23-25 Für Leckage und Batteriestatus gibt es sichtbare Alarmsignale, für den Therapiebeginn ein Notizfeld und zur Optimierung der Tragedauer einen Indikator für einen vollen Verband21,22 PICO sNPWT reduziert zudem nachweislich die laterale Spannung*8 an der Naht NPWT kann zudem zur Reduzierung von Ödemen beitragen9-11 Gleichzeitig werden LymphdrainageÜÜ12 und Angiogenese26,27 gefördert Die Therapieeinheit ist geräuscharm und verfügt über einen Gürtel-Clip16 Das Produkt ist unter anderem einsetzbar Für verschlossene Inzisionen Im Krankenhaus In der häuslichen Pflegeumgebung Im Set enthalten sind Die Therapieeinheit Ein Gürtel-Clip 2 Verbände 6 Fixierstreifen *Wie in biomechanischen Modellversuchen nachgewiesen **In vivo nachgewiesen ***Wie in Labortests nachgewiesen 1 Hudson DA, et al. Int Wound J. 2015;12(2):195-201 2 Smith+Nephew 2019. Internal Report. RD/18/134 V2 3 Smith+Nephew 2017. Internal Report. DS/17/253/R 4 Saunders C, et al. BJS open. 2021 Jan;5(1):zraa003 5 Casey C. Consistent delivery of therapeutic negative pressure levels by a single use negative pressure wound therapy system (sNPWT)* in a wound model. Paper presented at: EWMA; 2019; Gothenburg, Sweden 6 Kirsner R, et al. Wound Repair Regen. 2019;27(5):519 - 529 7 Smith+Nephew 2018. Internal Report. DS.18.260.R 8 Loveluck J, et al. ePlasty. 2016;16:183-195 9 Birke-Sorensen H, et al. J Plast Reconstr Aesthet Surg. 2011;64 Suppl:S1-16 10 Kamolz LP, et al. Burns. 2004;30(3):253-258 11 Molnar JA, et al. J Burns Wounds. 2005;4:83-92 12 Kilpadi DV, et al. Wound Repair Regen. 2011;19(5):588-596 13 Payne C, et al. ePlasty. 2014:152-166 14 Stryja J, et al. Prolekare. 2015;94(8):322 - 328 15 Smith+Nephew 2015. Internal Report. ST865 CT09/02 16 Smith+Nephew 2018. Internal Report. RD/18/131 17 Gilchrist B, et al. Performance, safety, and efficacy of a single use negative pressure wound therapy system for surgically closed incision sites and skin grafts: A prospective multi-centre follow-up study. Paper presented at: SAWC; 2020; Virtual 18 Smith+Nephew 2020. Internal Report. 2001002 19 Smith+Nephew. Internal Report. RD/18/137 20 Smith+Nephew 2018. Internal Report. DS.18.066.R 21 Karlakki SL, et al. Bone Joint Res. 2016;5(8):328-337 22 Dingemans SA, et al. Int Orthop. 2018;42(4):747-753 23 Clark JM, et al. J Otolaryngol Head Neck Surg. 2019;48(1):21 24 Smith+Nephew 2018. Internal Report. RD/18/136 25 Smith+Nephew 2018. Internal Report. RD/18/133 26 Ma Z, Shou K, Li Z, et al. Negative pressure wound therapy promotes vessel destabilization and maturation at various stages of wound healing and thus influences wound prognosis. Exp Ther Med. 2016;11(4):1307-1317 27 Xia CY, Yu AX, Qi B, et al. Analysis of blood flow and local expression of angiogenesis associated growth factors in infected wounds treated with negative pressure wound therapy. Mol Med Rep. 2014;9(5):1749-1754

PICO 7 kanisterloses Unterdruck-Wundtherapiesystem Das System ist tragbar, leicht und diskret - für mehr Patientenfreiheit.17-20 Produkteigenschaften Das PICO 7 kanisterlose Unterdruck-Wundtherapiesystem verfügt über die AIRLOCK-Technologie So wird ein konstanter Unterdruck abgegeben - bis zu 7 Tage Der Unterdruck von -80mmHG wird über die gesamte Wundauflage aufrechterhalten - dank des einzigartigen Verbanddesigns wird so ein erweitertes Therapieareal der Vakuumversiegelung ermöglicht Auch ohne vollständige Versiegelung (Leckage)***5 Oder schwer zu verbindenden Körperkonturen23-25 Für Leckage und Batteriestatus gibt es sichtbare Alarmsignale, für den Therapiebeginn ein Notizfeld und zur Optimierung der Tragedauer einen Indikator für einen vollen Verband21,22 PICO sNPWT reduziert zudem nachweislich die laterale Spannung*8 an der Naht NPWT kann zudem zur Reduzierung von Ödemen beitragen9-11 Gleichzeitig werden LymphdrainageÜÜ12 und Angiogenese26,27 gefördert Die Therapieeinheit ist geräuscharm und verfügt über einen Gürtel-Clip16 Das Produkt ist unter anderem einsetzbar Für verschlossene Inzisionen Im Krankenhaus In der häuslichen Pflegeumgebung Im Set enthalten sind Die Therapieeinheit Ein Gürtel-Clip 2 Verbände 6 Fixierstreifen *Wie in biomechanischen Modellversuchen nachgewiesen **In vivo nachgewiesen ***Wie in Labortests nachgewiesen 1 Hudson DA, et al. Int Wound J. 2015;12(2):195-201 2 Smith+Nephew 2019. Internal Report. RD/18/134 V2 3 Smith+Nephew 2017. Internal Report. DS/17/253/R 4 Saunders C, et al. BJS open. 2021 Jan;5(1):zraa003 5 Casey C. Consistent delivery of therapeutic negative pressure levels by a single use negative pressure wound therapy system (sNPWT)* in a wound model. Paper presented at: EWMA; 2019; Gothenburg, Sweden 6 Kirsner R, et al. Wound Repair Regen. 2019;27(5):519 - 529 7 Smith+Nephew 2018. Internal Report. DS.18.260.R 8 Loveluck J, et al. ePlasty. 2016;16:183-195 9 Birke-Sorensen H, et al. J Plast Reconstr Aesthet Surg. 2011;64 Suppl:S1-16 10 Kamolz LP, et al. Burns. 2004;30(3):253-258 11 Molnar JA, et al. J Burns Wounds. 2005;4:83-92 12 Kilpadi DV, et al. Wound Repair Regen. 2011;19(5):588-596 13 Payne C, et al. ePlasty. 2014:152-166 14 Stryja J, et al. Prolekare. 2015;94(8):322 - 328 15 Smith+Nephew 2015. Internal Report. ST865 CT09/02 16 Smith+Nephew 2018. Internal Report. RD/18/131 17 Gilchrist B, et al. Performance, safety, and efficacy of a single use negative pressure wound therapy system for surgically closed incision sites and skin grafts: A prospective multi-centre follow-up study. Paper presented at: SAWC; 2020; Virtual 18 Smith+Nephew 2020. Internal Report. 2001002 19 Smith+Nephew. Internal Report. RD/18/137 20 Smith+Nephew 2018. Internal Report. DS.18.066.R 21 Karlakki SL, et al. Bone Joint Res. 2016;5(8):328-337 22 Dingemans SA, et al. Int Orthop. 2018;42(4):747-753 23 Clark JM, et al. J Otolaryngol Head Neck Surg. 2019;48(1):21 24 Smith+Nephew 2018. Internal Report. RD/18/136 25 Smith+Nephew 2018. Internal Report. RD/18/133 26 Ma Z, Shou K, Li Z, et al. Negative pressure wound therapy promotes vessel destabilization and maturation at various stages of wound healing and thus influences wound prognosis. Exp Ther Med. 2016;11(4):1307-1317 27 Xia CY, Yu AX, Qi B, et al. Analysis of blood flow and local expression of angiogenesis associated growth factors in infected wounds treated with negative pressure wound therapy. Mol Med Rep. 2014;9(5):1749-1754

PICO 7 kanisterloses Unterdruck-Wundtherapiesystem Das System ist tragbar, leicht und diskret - für mehr Patientenfreiheit.17-20 Produkteigenschaften Das PICO 7 kanisterlose Unterdruck-Wundtherapiesystem verfügt über die AIRLOCK-Technologie So wird ein konstanter Unterdruck abgegeben - bis zu 7 Tage Der Unterdruck von -80mmHG wird über die gesamte Wundauflage aufrechterhalten - dank des einzigartigen Verbanddesigns wird so ein erweitertes Therapieareal der Vakuumversiegelung ermöglicht Auch ohne vollständige Versiegelung (Leckage)***5 Oder schwer zu verbindenden Körperkonturen23-25 Für Leckage und Batteriestatus gibt es sichtbare Alarmsignale, für den Therapiebeginn ein Notizfeld und zur Optimierung der Tragedauer einen Indikator für einen vollen Verband21,22 PICO sNPWT reduziert zudem nachweislich die laterale Spannung*8 an der Naht NPWT kann zudem zur Reduzierung von Ödemen beitragen9-11 Gleichzeitig werden LymphdrainageÜÜ12 und Angiogenese26,27 gefördert Die Therapieeinheit ist geräuscharm und verfügt über einen Gürtel-Clip16 Das Produkt ist unter anderem einsetzbar Für verschlossene Inzisionen Im Krankenhaus In der häuslichen Pflegeumgebung Im Set enthalten sind Die Therapieeinheit Ein Gürtel-Clip 2 Verbände 6 Fixierstreifen *Wie in biomechanischen Modellversuchen nachgewiesen **In vivo nachgewiesen ***Wie in Labortests nachgewiesen 1 Hudson DA, et al. Int Wound J. 2015;12(2):195-201 2 Smith+Nephew 2019. Internal Report. RD/18/134 V2 3 Smith+Nephew 2017. Internal Report. DS/17/253/R 4 Saunders C, et al. BJS open. 2021 Jan;5(1):zraa003 5 Casey C. Consistent delivery of therapeutic negative pressure levels by a single use negative pressure wound therapy system (sNPWT)* in a wound model. Paper presented at: EWMA; 2019; Gothenburg, Sweden 6 Kirsner R, et al. Wound Repair Regen. 2019;27(5):519 - 529 7 Smith+Nephew 2018. Internal Report. DS.18.260.R 8 Loveluck J, et al. ePlasty. 2016;16:183-195 9 Birke-Sorensen H, et al. J Plast Reconstr Aesthet Surg. 2011;64 Suppl:S1-16 10 Kamolz LP, et al. Burns. 2004;30(3):253-258 11 Molnar JA, et al. J Burns Wounds. 2005;4:83-92 12 Kilpadi DV, et al. Wound Repair Regen. 2011;19(5):588-596 13 Payne C, et al. ePlasty. 2014:152-166 14 Stryja J, et al. Prolekare. 2015;94(8):322 - 328 15 Smith+Nephew 2015. Internal Report. ST865 CT09/02 16 Smith+Nephew 2018. Internal Report. RD/18/131 17 Gilchrist B, et al. Performance, safety, and efficacy of a single use negative pressure wound therapy system for surgically closed incision sites and skin grafts: A prospective multi-centre follow-up study. Paper presented at: SAWC; 2020; Virtual 18 Smith+Nephew 2020. Internal Report. 2001002 19 Smith+Nephew. Internal Report. RD/18/137 20 Smith+Nephew 2018. Internal Report. DS.18.066.R 21 Karlakki SL, et al. Bone Joint Res. 2016;5(8):328-337 22 Dingemans SA, et al. Int Orthop. 2018;42(4):747-753 23 Clark JM, et al. J Otolaryngol Head Neck Surg. 2019;48(1):21 24 Smith+Nephew 2018. Internal Report. RD/18/136 25 Smith+Nephew 2018. Internal Report. RD/18/133 26 Ma Z, Shou K, Li Z, et al. Negative pressure wound therapy promotes vessel destabilization and maturation at various stages of wound healing and thus influences wound prognosis. Exp Ther Med. 2016;11(4):1307-1317 27 Xia CY, Yu AX, Qi B, et al. Analysis of blood flow and local expression of angiogenesis associated growth factors in infected wounds treated with negative pressure wound therapy. Mol Med Rep. 2014;9(5):1749-1754

PICO 7 kanisterloses Unterdruck-Wundtherapiesystem Das System ist tragbar, leicht und diskret - für mehr Patientenfreiheit.17-20 Produkteigenschaften Das PICO 7 kanisterlose Unterdruck-Wundtherapiesystem verfügt über die AIRLOCK-Technologie So wird ein konstanter Unterdruck abgegeben - bis zu 7 Tage Der Unterdruck von -80mmHG wird über die gesamte Wundauflage aufrechterhalten - dank des einzigartigen Verbanddesigns wird so ein erweitertes Therapieareal der Vakuumversiegelung ermöglicht Auch ohne vollständige Versiegelung (Leckage)***5 Oder schwer zu verbindenden Körperkonturen23-25 Für Leckage und Batteriestatus gibt es sichtbare Alarmsignale, für den Therapiebeginn ein Notizfeld und zur Optimierung der Tragedauer einen Indikator für einen vollen Verband21,22 PICO sNPWT reduziert zudem nachweislich die laterale Spannung*8 an der Naht NPWT kann zudem zur Reduzierung von Ödemen beitragen9-11 Gleichzeitig werden LymphdrainageÜÜ12 und Angiogenese26,27 gefördert Die Therapieeinheit ist geräuscharm und verfügt über einen Gürtel-Clip16 Das Produkt ist unter anderem einsetzbar Für verschlossene Inzisionen Im Krankenhaus In der häuslichen Pflegeumgebung Im Set enthalten sind Die Therapieeinheit Ein Gürtel-Clip 2 Verbände 6 Fixierstreifen *Wie in biomechanischen Modellversuchen nachgewiesen **In vivo nachgewiesen ***Wie in Labortests nachgewiesen 1 Hudson DA, et al. Int Wound J. 2015;12(2):195-201 2 Smith+Nephew 2019. Internal Report. RD/18/134 V2 3 Smith+Nephew 2017. Internal Report. DS/17/253/R 4 Saunders C, et al. BJS open. 2021 Jan;5(1):zraa003 5 Casey C. Consistent delivery of therapeutic negative pressure levels by a single use negative pressure wound therapy system (sNPWT)* in a wound model. Paper presented at: EWMA; 2019; Gothenburg, Sweden 6 Kirsner R, et al. Wound Repair Regen. 2019;27(5):519 - 529 7 Smith+Nephew 2018. Internal Report. DS.18.260.R 8 Loveluck J, et al. ePlasty. 2016;16:183-195 9 Birke-Sorensen H, et al. J Plast Reconstr Aesthet Surg. 2011;64 Suppl:S1-16 10 Kamolz LP, et al. Burns. 2004;30(3):253-258 11 Molnar JA, et al. J Burns Wounds. 2005;4:83-92 12 Kilpadi DV, et al. Wound Repair Regen. 2011;19(5):588-596 13 Payne C, et al. ePlasty. 2014:152-166 14 Stryja J, et al. Prolekare. 2015;94(8):322 - 328 15 Smith+Nephew 2015. Internal Report. ST865 CT09/02 16 Smith+Nephew 2018. Internal Report. RD/18/131 17 Gilchrist B, et al. Performance, safety, and efficacy of a single use negative pressure wound therapy system for surgically closed incision sites and skin grafts: A prospective multi-centre follow-up study. Paper presented at: SAWC; 2020; Virtual 18 Smith+Nephew 2020. Internal Report. 2001002 19 Smith+Nephew. Internal Report. RD/18/137 20 Smith+Nephew 2018. Internal Report. DS.18.066.R 21 Karlakki SL, et al. Bone Joint Res. 2016;5(8):328-337 22 Dingemans SA, et al. Int Orthop. 2018;42(4):747-753 23 Clark JM, et al. J Otolaryngol Head Neck Surg. 2019;48(1):21 24 Smith+Nephew 2018. Internal Report. RD/18/136 25 Smith+Nephew 2018. Internal Report. RD/18/133 26 Ma Z, Shou K, Li Z, et al. Negative pressure wound therapy promotes vessel destabilization and maturation at various stages of wound healing and thus influences wound prognosis. Exp Ther Med. 2016;11(4):1307-1317 27 Xia CY, Yu AX, Qi B, et al. Analysis of blood flow and local expression of angiogenesis associated growth factors in infected wounds treated with negative pressure wound therapy. Mol Med Rep. 2014;9(5):1749-1754

PICO 7 kanisterloses Unterdruck-Wundtherapiesystem Das System ist tragbar, leicht und diskret - für mehr Patientenfreiheit.17-20 Produkteigenschaften Das PICO 7 kanisterlose Unterdruck-Wundtherapiesystem verfügt über die AIRLOCK-Technologie So wird ein konstanter Unterdruck abgegeben - bis zu 7 Tage Der Unterdruck von -80mmHG wird über die gesamte Wundauflage aufrechterhalten - dank des einzigartigen Verbanddesigns wird so ein erweitertes Therapieareal der Vakuumversiegelung ermöglicht Auch ohne vollständige Versiegelung (Leckage)***5 Oder schwer zu verbindenden Körperkonturen23-25 Für Leckage und Batteriestatus gibt es sichtbare Alarmsignale, für den Therapiebeginn ein Notizfeld und zur Optimierung der Tragedauer einen Indikator für einen vollen Verband21,22 PICO sNPWT reduziert zudem nachweislich die laterale Spannung*8 an der Naht NPWT kann zudem zur Reduzierung von Ödemen beitragen9-11 Gleichzeitig werden LymphdrainageÜÜ12 und Angiogenese26,27 gefördert Die Therapieeinheit ist geräuscharm und verfügt über einen Gürtel-Clip16 Das Produkt ist unter anderem einsetzbar Für verschlossene Inzisionen Im Krankenhaus In der häuslichen Pflegeumgebung Im Set enthalten sind Die Therapieeinheit Ein Gürtel-Clip 2 Verbände 6 Fixierstreifen *Wie in biomechanischen Modellversuchen nachgewiesen **In vivo nachgewiesen ***Wie in Labortests nachgewiesen 1 Hudson DA, et al. Int Wound J. 2015;12(2):195-201 2 Smith+Nephew 2019. Internal Report. RD/18/134 V2 3 Smith+Nephew 2017. Internal Report. DS/17/253/R 4 Saunders C, et al. BJS open. 2021 Jan;5(1):zraa003 5 Casey C. Consistent delivery of therapeutic negative pressure levels by a single use negative pressure wound therapy system (sNPWT)* in a wound model. Paper presented at: EWMA; 2019; Gothenburg, Sweden 6 Kirsner R, et al. Wound Repair Regen. 2019;27(5):519 - 529 7 Smith+Nephew 2018. Internal Report. DS.18.260.R 8 Loveluck J, et al. ePlasty. 2016;16:183-195 9 Birke-Sorensen H, et al. J Plast Reconstr Aesthet Surg. 2011;64 Suppl:S1-16 10 Kamolz LP, et al. Burns. 2004;30(3):253-258 11 Molnar JA, et al. J Burns Wounds. 2005;4:83-92 12 Kilpadi DV, et al. Wound Repair Regen. 2011;19(5):588-596 13 Payne C, et al. ePlasty. 2014:152-166 14 Stryja J, et al. Prolekare. 2015;94(8):322 - 328 15 Smith+Nephew 2015. Internal Report. ST865 CT09/02 16 Smith+Nephew 2018. Internal Report. RD/18/131 17 Gilchrist B, et al. Performance, safety, and efficacy of a single use negative pressure wound therapy system for surgically closed incision sites and skin grafts: A prospective multi-centre follow-up study. Paper presented at: SAWC; 2020; Virtual 18 Smith+Nephew 2020. Internal Report. 2001002 19 Smith+Nephew. Internal Report. RD/18/137 20 Smith+Nephew 2018. Internal Report. DS.18.066.R 21 Karlakki SL, et al. Bone Joint Res. 2016;5(8):328-337 22 Dingemans SA, et al. Int Orthop. 2018;42(4):747-753 23 Clark JM, et al. J Otolaryngol Head Neck Surg. 2019;48(1):21 24 Smith+Nephew 2018. Internal Report. RD/18/136 25 Smith+Nephew 2018. Internal Report. RD/18/133 26 Ma Z, Shou K, Li Z, et al. Negative pressure wound therapy promotes vessel destabilization and maturation at various stages of wound healing and thus influences wound prognosis. Exp Ther Med. 2016;11(4):1307-1317 27 Xia CY, Yu AX, Qi B, et al. Analysis of blood flow and local expression of angiogenesis associated growth factors in infected wounds treated with negative pressure wound therapy. Mol Med Rep. 2014;9(5):1749-1754

PICO 7 kanisterloses Unterdruck-Wundtherapiesystem Das System ist tragbar, leicht und diskret - für mehr Patientenfreiheit.17-20 Produkteigenschaften Das PICO 7 kanisterlose Unterdruck-Wundtherapiesystem verfügt über die AIRLOCK-Technologie So wird ein konstanter Unterdruck abgegeben - bis zu 7 Tage Der Unterdruck von -80mmHG wird über die gesamte Wundauflage aufrechterhalten - dank des einzigartigen Verbanddesigns wird so ein erweitertes Therapieareal der Vakuumversiegelung ermöglicht Auch ohne vollständige Versiegelung (Leckage)***5 Oder schwer zu verbindenden Körperkonturen23-25 Für Leckage und Batteriestatus gibt es sichtbare Alarmsignale, für den Therapiebeginn ein Notizfeld und zur Optimierung der Tragedauer einen Indikator für einen vollen Verband21,22 PICO sNPWT reduziert zudem nachweislich die laterale Spannung*8 an der Naht NPWT kann zudem zur Reduzierung von Ödemen beitragen9-11 Gleichzeitig werden LymphdrainageÜÜ12 und Angiogenese26,27 gefördert Die Therapieeinheit ist geräuscharm und verfügt über einen Gürtel-Clip16 Das Produkt ist unter anderem einsetzbar Für verschlossene Inzisionen Im Krankenhaus In der häuslichen Pflegeumgebung Im Set enthalten sind Die Therapieeinheit Ein Gürtel-Clip 2 Verbände 6 Fixierstreifen *Wie in biomechanischen Modellversuchen nachgewiesen **In vivo nachgewiesen ***Wie in Labortests nachgewiesen 1 Hudson DA, et al. Int Wound J. 2015;12(2):195-201 2 Smith+Nephew 2019. Internal Report. RD/18/134 V2 3 Smith+Nephew 2017. Internal Report. DS/17/253/R 4 Saunders C, et al. BJS open. 2021 Jan;5(1):zraa003 5 Casey C. Consistent delivery of therapeutic negative pressure levels by a single use negative pressure wound therapy system (sNPWT)* in a wound model. Paper presented at: EWMA; 2019; Gothenburg, Sweden 6 Kirsner R, et al. Wound Repair Regen. 2019;27(5):519 - 529 7 Smith+Nephew 2018. Internal Report. DS.18.260.R 8 Loveluck J, et al. ePlasty. 2016;16:183-195 9 Birke-Sorensen H, et al. J Plast Reconstr Aesthet Surg. 2011;64 Suppl:S1-16 10 Kamolz LP, et al. Burns. 2004;30(3):253-258 11 Molnar JA, et al. J Burns Wounds. 2005;4:83-92 12 Kilpadi DV, et al. Wound Repair Regen. 2011;19(5):588-596 13 Payne C, et al. ePlasty. 2014:152-166 14 Stryja J, et al. Prolekare. 2015;94(8):322 - 328 15 Smith+Nephew 2015. Internal Report. ST865 CT09/02 16 Smith+Nephew 2018. Internal Report. RD/18/131 17 Gilchrist B, et al. Performance, safety, and efficacy of a single use negative pressure wound therapy system for surgically closed incision sites and skin grafts: A prospective multi-centre follow-up study. Paper presented at: SAWC; 2020; Virtual 18 Smith+Nephew 2020. Internal Report. 2001002 19 Smith+Nephew. Internal Report. RD/18/137 20 Smith+Nephew 2018. Internal Report. DS.18.066.R 21 Karlakki SL, et al. Bone Joint Res. 2016;5(8):328-337 22 Dingemans SA, et al. Int Orthop. 2018;42(4):747-753 23 Clark JM, et al. J Otolaryngol Head Neck Surg. 2019;48(1):21 24 Smith+Nephew 2018. Internal Report. RD/18/136 25 Smith+Nephew 2018. Internal Report. RD/18/133 26 Ma Z, Shou K, Li Z, et al. Negative pressure wound therapy promotes vessel destabilization and maturation at various stages of wound healing and thus influences wound prognosis. Exp Ther Med. 2016;11(4):1307-1317 27 Xia CY, Yu AX, Qi B, et al. Analysis of blood flow and local expression of angiogenesis associated growth factors in infected wounds treated with negative pressure wound therapy. Mol Med Rep. 2014;9(5):1749-1754